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THE REGENERATIVE POTENTIAL OF PERIPHERAL NERVES

The peripheral nervous system has the ability to recover after injury[61]

Fortunately the axon of the PNS can “repair themselves” and regain function after injury, which does not occur with CNS axons[61,62].
The potential for spontaneous repair of peripheral nerves is made possible by the remarkable adaptability of Schwann cells. Consequently, when a nerve sustains an injury, Schwann cells trigger a reparative and regenerative process that supports neuron survival, breaks down the damaged axon, and remyelinates the regenerated axon, among other essential processes.[63].
Both the presence of molecules external to the neuron (extracellular) and the neuron’s own growth capacity influence the success of this regenerative process[61].
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Bibliographic references

3. Neuropatía periférica | NINDS Español. https://espanol.ninds.nih.gov/es/trastornos/forma-larga/neuropatia-peri… (último acceso junio 23, 2021).

4. Casademont Pou J. Neuropatías: concepto, manifestaciones clínicas, clasificación, diagnóstico, pruebas complementarias y estrategias terapéuticas. Med – Programa Form Médica Contin Acreditado 2003;8:5373–8. doi:10.1016/s0304-5412(03)70997-4.

5. Watson JC, Dyck PJB. Peripheral Neuropathy: A Practical Approach to Diagnosis and Symptom Management. Mayo Clin Proc 2015;90:940–51. doi:10.1016/j.mayocp.2015.05.004.

6. Barrell K, Smith AG. Peripheral Neuropathy. Med Clin North Am 2019;103:383–97. doi:10.1016/j.mcna.2018.10.006.

7. Negrão L, Almeida P, Alcino S, Duro H, Libório T, Melo Silva U, et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag 2014;4:191–6. doi:10.2217/pmt.14.10.

8. Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep 2019;19:86. doi:10.1007/s11892-019-1212-8.

9. Neuropatía periférica – Síntomas y causas – Mayo Clinic. https://www.mayoclinic.org/es-es/diseases-conditions/peripheral-neuropa… (último acceso junio 23, 2021).

10. Castelli G, Desai K, Cantone R. Peripheral Neuropathy: Evaluation and Differential Diagnosis – PubMed. Am Fam Physician 2020;102:732–9.

11. Galán MGM, Alonso JJR, García HV. Neuropatías por atrapamiento. FMC Form Médica Contin en Atención Primaria. 2008;15(1):10-20. doi:10.1016/S1134-2072(08)70726-6

32. Pradilla G. Diagnóstico y tratamiento de las neuropatías periféricas Diagnóstico y tratamiento de las neuropatías periféricas. https://www.acnweb.org/guia/g5cap14.pdf (último acceso abril 25, 2022).

45. Manji H. Toxic neuropathy. Curr Opin Neurol. 2011;24(5):484-490. doi:10.1097/WCO.0B013E32834A94B6

 

Revised content: July 11, 2022.