NUCLEOTIDES AND VITAMINS

What are nucleotides?

Nucleotides are building blocks of nucleic acids, DNA and RNA, which are essential for the growth and repair of nerve cells.

During nerve regeneration, damaged nerve cells need to rebuild and restore their structure and function. Nucleotides, as the building blocks of DNA and RNA, provide the necessary components needed for this process.¹

Nucleotides are semi-essential nutrients. This means, that in certain situations, the body cannot make enough to meet demands and they must be obtained through the diet.¹ As food sources are limited, meeting the required amounts through diet alone can be difficult.²By supplying an adequate amount of nucleotides through dietary supplements, the body has the necessary resources to support nerve regeneration and optimise the repair process.

The supply of neurotropic B complex vitamins contributes to the normal functioning of the nervous system

Vitamins are compounds that play a crucial role in various bodily functions. As humans are unable to produce B vitamins on their own, they must obtain an adequate supply from the diet^[65].

Bibliographic references

1. Manhães M, Cesar M, Justo R, Geller M, Suchmacher M, Cisne R. The Role of Nucleotides in Glial Cells during Peripheral Nerve Trauma and Compressive Disorders. En Maurício AC, ed. Peripheral Nerve Regeneration – From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Development. Croacia: InTech; 2017.

2. Danilov A.B., Kurushina O.V., Prokopenko S.V., Karakulova Y.V., Shcherbanosova T.A., Shirokov V.A., Chuprina S.E., Komarov A.N., Kurganova Y.M. Improvement in acute low back pain and quality of life in patients by the addition of a combination of uridine monophosphate, folic acid, and vitamin B12 to standard therapy. Manage Pain. 2022. 34-41.

65. Calderón-Ospina CA, Nava-Mesa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther 2020;26:5–13. doi:10.1111/cns.13207.

67. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of health claims related to vitamin B12 and contribution to normal neurological and psychological functions (ID 95, 97, 98, 100, 102, 109), contribution to normal homocysteine metabolism (ID 96, 103, 106), maintenance of normal bone (ID 104), maintenance of normal teeth (ID 104), maintenance of normal hair (ID 104), maintenance of normal skin (ID 104), maintenance of normal nails (ID 104), reduction of tiredness and fatigue (ID 108), and cell division (ID 212) pursuant to Article 13 (1) of Regulation (EC) No 1924/2006. EFSA Journal 2010;8(10):175