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Learn how nucleotides help support nerve regeneration and why they matter in clinical care

Clinical studies on nucleotides in various peripheral neuropathies suggest potential benefits, including:

Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies
https://pubmed.ncbi.nlm.nih.gov/24835269
Nucleotides Cytidine and Uridine Associated with Vitamin B₁₂ vs. B‑Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study
https://pubmed.ncbi.nlm.nih.gov/33116795
3.Effectiveness of the use of a combination of uridine monophosphate, folic acid, and vitamin B₁₂ in chronic lumbar pain due to radiculopathy
https://pubmed.ncbi.nlm.nih.gov/24835269
Evaluation of the Efficacy of the Addition of a Combination of Pyrimidine Nucleotides and Vitamin B₁ and B₁₂ to Standard Treatment in the Management of Painful Radiculopathy and in the Quality of Life of Patients
https://doi.org/10.3390/nu16234187
Efficiency of pyrimidine nucleotides in the complex treatment of patients with type 2 diabetes mellitus
https://www.thepharmajournal.com/archives/?year=2016&vol=5&issue=9&ArticleId=862

Negrão, L., Almeida, P., Alcino, S., et al. (2014). Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain management, 4 3, 191-6 .
Skrypko L, Gryb V, Skrypko V. Pharma Innovation. 2016;5(9):68-71.
Monfort J, Carrión-Barberà I, Tío L et al. Efficacy of the Addition of a Combination of Pyrimidine Nucleotides and Vitamin B1 and B12 to Standard Treatment in the Management of Painful Radiculopathy and in the Quality of Life of Patients. Nutrients 2024:16:418
Manhães M, Cesar M, Justo R, Geller M, Suchmacher M, Cisne R. The Role of Nucleotides in Glial Cells during Peripheral Nerve Trauma and Compressive Disorders. En Maurício AC, ed. Peripheral Nerve Regeneration – From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Development. Croacia: InTech; 2017.